Adiflam 50Mg (Blister)
- Stock: 19333
- Model: Adiflam 50Mg (Blister)
- Pack Size: 200
- SKU: 000259
- Pack size: 200
- Generic name: Diclofenac Sodium
DESCRIPTION Diclofenac a very commonly used non-steroidal anti-inflammatory drug, has analgesic, anti-pyretic actions. Diclofenac provides a novel NSAID for quick relief from pain, swelling inflammation, Adiflam is a brand name which stands for “Against the Flammarion”. Adiflam-SR tablet is specially formulated to release the Diclofenac Sodium slowly. Adiflam Gel: Topical product for joints & muscular pain, anti-inflammatory preparations.
CLINICAL PHARMACOLOGY: Pharmacotherapeutic group: non-steroidal anti-inflammatory drugs (NSAlDs): It is an inhibitor of prostaglandin synthetase, (cyclo-oxygenase). Diclofenac sodium in vitro does not suppress proteoglycan biosynthesis in cartilage at concentrations equivalent to the concentrations reached in human beings.
PHARMACOKINETIC: Adiflam/Adiflam SR Tablet (Diclofenac Sodium): Absorption is complete, but onset is delayed until passage through the stomach, which may be affected by food which delays stomach emptying. The active substance is 99.7% protein bound, mainly to albumin (99.4%). Biotransformation Of diclofenac takes place partly by glucuronidation of the intact molecule. but mainly by single and multiple hydroxylation and methylation, resulting in several phenolic metabolites, most of which are converted to glucuronide conjugates. About 60% of the administered dose is excreted in the urine in the form of the glucuronide conjugate of the intact molecule and as metabolites. most of which are also converted to glucuronide conjugates. Less than 1% is excreted as unchanged substance. The rest of the dose is eliminated as metabolites through the bile in the faces. Adiflam Gel (Diclofenac Dimethylamine): When applied locally. the active substance is absorbed through the skin. In healthy volunteers approximately 6% of the dose applied is absorbed. as determined by urinary excretion of diclofenac and its hydroxylated metabolites. Findings in patients confirm that diclofenac penetrates inflamed areas following local application of Adiflam Gel. After topical administration of Adiflam Gel to hand and knee joints diclofenac can be measured in plasma. synovial tissue and synovial fluid. Maximum plasma concentrations of diclofenac are about 100 times lower than after oral administration of Diclofenac.
INDICATIONS: Adiflam/Adiflam-SR Tablet (Diclofenac Sodium): is indicated for rheumatoid arthritis, osteoarthritis, Low back pain, ankylosing spondylitis, gout, acute musculoskeletal disorders, periarthritis (frozen shoulder), tendinitis, tenosynovitis, bursitis, sprains, dislocations, painful post-operative conditions, pain following dental surgery & painful inflammatory conditions in gynecology. Adiflam Gel (Diclofenac Dimethylamine): This topical analgesic is indicated for the temporary relief of minor aches and pains of muscles and joints due to muscle strains, sprains and bruise or over exertion, as an adjunct in the management of minor stiffness or sourness associated with arthritis, rheumatism, lumbago, fibrositis, sciatica and stiff neck.
INTERACTION: ACE Inhibitors: Increased risk of renal impairment when NSAlDs given with ACE inhibitors, also hypotensive effect antagonized. Adrenergic Neuron Blockers: NSAlDs antagonize hypotensive effect of adrenergic neuron blocker. Beta Blockers: NSAIDs antagonize hypotensive effect of Beta blocker. Cardiac Glycosides: NSAIDs possibly increase the plasma concentration of cardiac glycosides, also possible exacerbation of heart failure and reduction of renal function. Diuretics: Risk of nephrotoxicity of NSAlDs increased by diuretics.
SIDE EFFECT: Gastro-intestinal disturbances including discomfort, nausea, diarrhea, and occasionally bleeding and ulceration occur. Systemic as well as local effects of NSAIDs contribute to gastro-intestinal damage, taking oral formulation with milk or food or using enteric coated formulation or changing the route of administration may only partially reduce symptoms such as dyspepsia.
Manufactured by: LEBEN LABORATORIES (PVT) LTD