Vitra D - 1000
Contents Each soft capsule contains Cholecalciferol 25 microgram Equiv. Vitamin D3 1000 IU
Description: Vitamin D3 deficiency in children can manifest as rickets (it is the most common cause of nutritional rickets), which presents as bowing of the legs. Vitamin D3 deficiency in adults’ results in osteocalcin, which presents as a poorly mineralized skeletal matrix. These adults can experience chronic muscle aches and pains. 1000 D (Vitamin D3) is important for calcium homeostasis and for optimal skeletal health. The major function of 1000 D (Vitamin D3) is to increase the efficiency of calcium absorption from the small intestine as maximum calcium absorption occurs there 1000 D (Vitamin D3) also enhances the absorption of phosphorus from the distal small bowel. Adequate calcium and phosphorus absorption from the intestine are important for proper mineralization of the bone. The second major function of 1000 D (Vitamin D3) is involvement in the maturation of osteoclasts, which resorb calcium from the bones.
Etiology: Vitamin D3 deficiency can result from the following: Inadequate exposure to sunlight - This causes a deficiency in cutaneous synthesized Vitamin D3; adults in nursing homes or healthcare institutions are at a particularly high risk. Vitamin D3 malabsorption problems-People who have undergone resection of the small intestine are at risk for this condition; diseases associated with Vitamin D3 malabsorption include celiac sprue, short bowel syndrome and cystic fibrosis. Minimal amounts of Vitamin D3 in human breast milk - The American Academy of Pediatrics recommends Vitamin D3 supplementation starting at age 2 months for infants fed exclusively with breast milk. Medications - Some medications are associated with Vitamin D deficiency; drugs such as Dilantin, phenobarbital, and rifampin can induce hepatic p450 enzymes to accelerate the catabolism of Vitamin D3.
Epidemiology: Vitamin D3 production in the skin declines with advancing age, making elderly populations more dependent on dietary Vitamin D3. For the average older person, higher dietary intake of Vitamin D3 may be required to achieve optimal serum levels. However, Vitamin D3 insufficiency is not restricted to the elderly and hospitalized population; several studies have found a high prevalence of Vitamin D3 deficiency among healthy, young adults. This deficiency is of equal proportions worldwide.
Prognosis: The treatment of Vitamin D3 insufficiency can decrease the risk of hip and non-vertebral fractures. (A meta-analysis by Boonen et al of postmenopausal women and of men aged 50 years or older reporting a risk of hip fracture found that oral Vitamin D3 supplementation reduced the risk of hip fractures by 18%.) Vitamin D3 supplementation has been associated with a reduction in falls and improved muscle strength in the elderly. (A meta-analysis demonstrated that Vitamin D3 supplementation resulted in a reduction in falls of about 22% in ambulatory and institutionalized elderly subjects, as compared with controls.)
Indication: 1000-D contains Vitamin D3, which helps prevent dietary Vitamin D deficiency. Vitamin D supports healthy immune system and cardiovascular system function. A diet deficient in calcium can lead to osteoporosis in later life. Vitamin D helps calcium absorption and supports bone health and mineralization.
Warning: Contain Sulfites & Soya bean products. Vitamin supplements should not replace a balanced diet. If symptoms persist, talk to your health professional.
Manufactured By: Contract Manufacturing & Packaging Services Pty Ltd